Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

T Hashiguchi, M Kajikawa, N Maita… - Proceedings of the …, 2007 - National Acad Sciences
Measles still remains a major cause of childhood morbidity and mortality worldwide. Measles
virus (MV) vaccines are highly successful, but the mechanism underlying their efficacy has …

[PDF][PDF] Structural basis for Marburg virus neutralization by a cross-reactive human antibody

T Hashiguchi, ML Fusco, ZA Bornholdt, JE Lee… - Cell, 2015 - cell.com
The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface,
termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ …

[HTML][HTML] Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant

…, A Saito, K Matsuno, K Takayama, T Hashiguchi… - Nature …, 2023 - nature.com
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike protein, …

[PDF][PDF] A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

…, Y Matsuura, T Suzuki, H Sawa, T Hashiguchi… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …

[PDF][PDF] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Y Kaku, T Kuwata, HM Zahid, T Hashiguchi, T Noda… - Cell reports, 2021 - cell.com
Administration of convalescent plasma or neutralizing monoclonal antibodies (mAbs) is a
potent therapeutic option for coronavirus disease 2019 (COVID-19) caused by severe acute …

[HTML][HTML] Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

…, G Schreiber, K Maenaka, T Hashiguchi… - Nature …, 2023 - nature.com
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is
spreading rapidly around the world. Our phylogenetic analyses suggested that XBB …

Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5

…, J Kuramochi, G Schreiber, KJ Ishii, T Hashiguchi… - Cell, 2022 - cell.com
After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including
BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical …

Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM

T Hashiguchi, T Ose, M Kubota, N Maita… - Nature structural & …, 2011 - nature.com
Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly
infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular …

[PDF][PDF] Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

…, S Aoki, K Kuramochi, T Suzuki, T Hashiguchi… - Iscience, 2021 - cell.com
Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …

[HTML][HTML] Mechanism of human antibody-mediated neutralization of Marburg virus

…, CD Murin, T Garron, X Shen, ML Fusco, T Hashiguchi… - Cell, 2015 - cell.com
The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known.
We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to …