Crystal structure of measles virus hemagglutinin provides insight into effective vaccines
T Hashiguchi, M Kajikawa, N Maita… - Proceedings of the …, 2007 - National Acad Sciences
Measles still remains a major cause of childhood morbidity and mortality worldwide. Measles
virus (MV) vaccines are highly successful, but the mechanism underlying their efficacy has …
virus (MV) vaccines are highly successful, but the mechanism underlying their efficacy has …
[PDF][PDF] Structural basis for Marburg virus neutralization by a cross-reactive human antibody
T Hashiguchi, ML Fusco, ZA Bornholdt, JE Lee… - Cell, 2015 - cell.com
The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface,
termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ …
termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ …
[HTML][HTML] Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike protein, …
variants convergently acquired amino acid substitutions at critical residues in the spike protein, …
[PDF][PDF] A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
…, Y Matsuura, T Suzuki, H Sawa, T Hashiguchi… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
[PDF][PDF] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19
Y Kaku, T Kuwata, HM Zahid, T Hashiguchi, T Noda… - Cell reports, 2021 - cell.com
Administration of convalescent plasma or neutralizing monoclonal antibodies (mAbs) is a
potent therapeutic option for coronavirus disease 2019 (COVID-19) caused by severe acute …
potent therapeutic option for coronavirus disease 2019 (COVID-19) caused by severe acute …
[HTML][HTML] Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
…, G Schreiber, K Maenaka, T Hashiguchi… - Nature …, 2023 - nature.com
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is
spreading rapidly around the world. Our phylogenetic analyses suggested that XBB …
spreading rapidly around the world. Our phylogenetic analyses suggested that XBB …
Virological characteristics of the SARS-CoV-2 Omicron BA. 2 subvariants, including BA. 4 and BA. 5
…, J Kuramochi, G Schreiber, KJ Ishii, T Hashiguchi… - Cell, 2022 - cell.com
After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including
BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical …
BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical …
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM
T Hashiguchi, T Ose, M Kubota, N Maita… - Nature structural & …, 2011 - nature.com
Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly
infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular …
infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular …
[PDF][PDF] Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
…, S Aoki, K Kuramochi, T Suzuki, T Hashiguchi… - Iscience, 2021 - cell.com
Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …
[HTML][HTML] Mechanism of human antibody-mediated neutralization of Marburg virus
…, CD Murin, T Garron, X Shen, ML Fusco, T Hashiguchi… - Cell, 2015 - cell.com
The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known.
We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to …
We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to …