Neuronal circuits in the brain are shaped by experience during 'critical periods' in early postnatal
life. In the primary visual cortex, this activity-dependent development is triggered by the …

Adult brain plasticity, although possible, remains more restricted in scope than during
development. Here, we address conditions under which circuit rewiring may be facilitated in the …

A continuing debate in language acquisition research is whether there are critical periods (CPs)
in development during which the system is most responsive to environmental input. …

▪ Abstract Neuronal circuits are shaped by experience during critical periods of early postnatal
life. The ability to control the timing, duration, and closure of these heightened levels of …

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent
refinement of functional connections within developing visual cortex was …

Loss-of-function mutations in human SCN1A gene encoding Na v 1.1 are associated with a
severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we …

Neuronal circuits across several systems display remarkable plasticity to sensory input during
postnatal development 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 . Experience-dependent refinements …

One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in
the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of …

Weak inhibition within visual cortex early in life prevents experience-dependent plasticity. Loss
of responsiveness to an eye deprived of vision can be initiated prematurely by enhancing …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …