Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue
and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of …

Inflammation is increasingly regarded as a key process underlying metabolic diseases in
obese individuals. In particular, obese adipose tissue shows features characteristic of active …

Metabolic syndrome is thought to result from obesity and obesity-linked insulin resistance.
Obesity in adulthood is characterized by adipocyte hypertrophy. Adipose tissue participates in …

INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1
receptor tyrosine kinases; it has an apparent relative molecular mass of 160–190,000 (M r , 160…

Background Several families have been described in which a mutation of mitochondrial DNA,
the substitution of guanine for adenine (A-to-G) at position 3243 of leucine transfer RNA, is …

OBJECTIVE—The high–molecular weight (HMW) form of adiponectin, an adipocyte-derived
insulin-sensitizing hormone, has been reported to be the most active form of this hormone. …

Corrigendum (2004) Adiponectin (also known as 30-kDa adipocyte complement-related
protein; Acrp30) 1 , 2 , 3 , 4 is a hormone secreted by adipocytes that acts as an antidiabetic 5 , …

Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity
through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The …

Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1
and AdipoR2 serve as receptors for adiponectin in vitro, and their reduction in obesity seems …

Context With increasing globalization and East-West exchanges, the increasing epidemic of
type 2 diabetes in Asia has far-reaching public health and socioeconomic implications. …