The integrin αVβ3 receptor has been implicated in several important diseases, but no
antagonists are approved for human therapy. One possible limitation of current small-molecule …

A sex pheromone component of Pseudococcus cryptus has been isolated and identified.
The crude pheromone extract obtained by airborne collection was fractionated by liquid …

G-protein-coupled receptor 52 (GPR52) is classified as an orphan Gs-coupled G-protein-coupled
receptor. GPR52 cancels dopamine D2 receptor signaling and activates dopamine D1/…

G protein-coupled receptor 52 (GPR52) agonists are expected to improve the symptoms of
psychiatric disorders. During exploration for a novel class of GPR52 agonists with good …

Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of
sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and …

A novel triple reuptake inhibitor with low potential of liabilities associated with cationic
amphiphilic drug (CAD) was identified following an analysis of existing drugs. Low molecular …

Two antifungal phthalides produced by a wheat rhizosphere fungus have been synthesized
using the Alder–Rickert reaction to construct their common isobenzofuranone core structure. …

The sex pheromone of the citrus mealybug (Pseudococcus cryptus), [(1R,3R)-3-isopropenyl-2,2-dimethylcyclobutyl]methyl
3-methyl-3-butenoate, was synthesized from (+)-α-pinene in …

Pteridic acid A (1) is a spirocyclic octaketide produced by the phytoepiphytic actinomycete
Streptomyces hygroscopicus TP‐A0451 and possesses potent plant‐growth‐promoting …

Enteropeptidase is located in the duodenum that involved in intestinal protein digestion. We
have reported enteropeptidase inhibitors with low systemic exposure. The aim of this study …