PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been
identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism …

The olfactory receptor (OR) superfamily provides a basis for the remarkable ability to
recognize and discriminate a large number of odorants. In mice, the superfamily includes ∼1000 …

Intestinal cancer is one of the most common human cancers. Aberrant activation of the
canonical Wnt signaling cascade, for example, caused by adenomatous polyposis coli (APC) …

Motivation: An amphiphilicity index of amino acid residues was developed for improving the
method of transmembrane helix prediction. Results: The transfer energy of a hydrocarbon …

Background Proneurotrophins and mature neurotrophins elicit opposite effects via the p75
neurotrophin receptor (p75 NTR ) and Trk tyrosine kinase receptors, respectively; however …

Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …

Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is a neuron-specific ubiquitin recycling
enzyme. A mutation at residue 93 and polymorphism at residue 18 within human UCH-L1 are …

The discovery of novel bioactive molecules advances our systems‐level understanding of
biological processes and is crucial for innovation in drug development. For this purpose, the …

Ras mutations (eg, occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and
promising drug targets in chemotherapy treatments for cancer. However, there are still no …

Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such
as cancer and autoimmune disease. Here, we report the crystal structure of human EP4 in …