Mesenchymal stem cells (MSCs) have emerged as a new therapeutic modality for
reconstituting the hematopoietic microenvironment by improving engraftment in stem cell …

The occurrence of delayed neutropenia following rituximab is poorly defined and of unknown
cause. We hypothesized it may be related to perturbations of stromal derived factor-1 (SDF-…

Multiple myeloma in humans is frequently associated with mast cell infiltration and
neovascularization, which correlate directly with disease severity, but the mechanisms underlying …

Mast cells (MCs) are common components of inflammatory infiltrates and a source of
proangiogenic factors. Inflammation is often accompanied by vascular changes. However, little is …

Macrothrombocytopenia with leukocyte inclusions is a rare autosomal dominant platelet
disorder characterized by a triad of giant platelets, thrombocytopenia, and characteristic Döhle …

Stressors contribute to thrombosis and insulin resistance. Since obesity-related adipose
inflammation is also involved in these pathological states, we assumed that stress correlates …

Stress is associated with pathophysiology of both irritable bowel syndrome (IBS) and
hypertension. Angiotensin receptor blockers (ARB) have anti-inflammatory properties via inhibition …

Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and
thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets …

Immune checkpoint inhibitors have now become a standard therapy for malignant melanoma.
However, as immunotherapies are effective in only a limited number of patients, biomarker …

Background Tumour-infiltrating lymphocyte (TIL)-high breast tumours have a high rate of
pathological complete response (pCR) with neoadjuvant chemotherapy. In our routine …