Targeted protein degradation using the auxin-inducible degron (AID) system is garnering
attention in the research field of Caenorhabditis elegans, because of the rapid and efficient …

β-catenin is a transcriptional cofactor mediating the "canonical" Wnt signaling pathway,
which activates target genes in a complex with TCF (LEF) transcription factors [1]. In many …

Background Orientation and positioning of the cell division plane are essential for generation
of invariant cleavage patterns and for unequal cell divisions during development. Precise …

Suppression of zygotic transcription in early embryonic germline cells is tightly linked to their
separation from the somatic lineage. Many invertebrate embryos utilize localized maternal …

IAA (1 mM) or IAA-AM (1 mM); elapsed time (hours: minutes) from the beginning of recording
is indicated. GFP panels show maximum intensity projection images, and green fluorescent …

10.7554/eLife.16550.001 In the last mitotic division of the epidermal lineage in the ascidian
embryo, the cells divide stereotypically along the anterior-posterior axis. During interphase, …

Gastrulation is the first major morphogenetic event during animal embryogenesis. Ascidian
gastrulation starts with the invagination of 10 endodermal precursor cells between the 64- …

The orientation of cell division can have important consequences on the choice of cell fates
adopted by each daughter cell as well as on the architecture of the tissue within which the …

Patterning of the vertebrate anterior–posterior axis is regulated by the coordinated action of
growth factors whose effects can be further modulated by upstream and downstream …

Asymmetric cell division during embryogenesis contributes to cell diversity by generating
daughter cells that adopt distinct developmental fates. In this chapter, we summarize current …