Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Mechanisms underlying human germ cell development are unclear, partly due to difficulties
in studying human embryos and lack of suitable experimental systems. Here, we show that …

Data on irradiation hardening and embrittlement of 8–10Cr normalized and tempered martensitic
steel (TMS) alloys has been compiled from the literature, including results from neutron…

Cancer is believed to arise primarily through accumulation of genetic mutations. Although
induced pluripotent stem cell (iPSC) generation does not require changes in genomic …

Dietary restriction is the most effective and reproducible intervention to extend lifespan in
divergent species 1 . In mammals, two regimens of dietary restriction, intermittent fasting (IF) …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation, …

Transcriptional initiation of each gene is assumed to be independently controlled in
mammals. On the other hand, recent large-scale transcriptome analyses have shown that the …

A highly complex network of coinhibitory and costimulatory receptors regulates the outcome
of virus-specific CD8 + T-cell responses. Here, we report on the expression patterns of …

The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent
stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we …