Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be annotated …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer’s and related dementias and cancer patients after chemo- or radio-…

Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component
senescence-associated secretory phenotype (SASP) that participates in several age-…

Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an …

Morquio A syndrome (mucopolysaccharidosis IVA ) is an autosomal recessive disorder that
results from deficient activity of the enzyme N ‐acetylgalactosamine‐6‐sulfatase ( GALNS ) …

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and
how age-related changes in somatic stem cells impact the faithful execution of lineage …

In adult epithelial stem cell lineages, the precise differentiation of daughter cells is critical to
maintain tissue homeostasis. Notch signaling controls the choice between absorptive and …

Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic
effects in mammals on normal and high-fat diets (HFD). We previously reported that …

Intestinal stem cells (ISCs) maintain regenerative capacity of the intestinal epithelium. Their
function and activity are regulated by transcriptional changes, yet how such changes are …