The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of ∆ 9
-tetrahydrocannabinol (∆ 9 -THC) and cannabidiol (CBD), comparatively little is known …

Sexual dimorphisms are observed in cannabinoid pharmacology. It is widely reported that
female animals are more sensitive to the cataleptic, hypothermic, antinociceptive, and anti‐…

Cannabinoid 1 receptor (CB1R) allosteric ligands hold a far-reaching therapeutic promise.
We report the application of fluoro- and nitrogen-walk approaches to enhance the drug-like …

Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment
options that address the spectrum of symptoms are limited, highlighting the need for …

Early-life environmental factors, such as maternal diet or early-life nutrition, have been described
as significant risk factors for anxiety and depression later in life. With the rising intake of …

The first synthetic cannabinoid receptor agonists (SCRAs) were designed as tool compounds
to study the endocannabinoid system’s two predominant cannabinoid receptors, CB1R …

We apply the magic methyl effect to improve the potency/efficacy of GAT211, the prototypic 2-phenylindole-based
cannabinoid type-1 receptor (CB1R) agonist-positive allosteric …

Cannabis sativa has gained popularity as a “natural substance”, leading many to falsely
assume that it is not harmful. This assumption has been documented amongst pregnant mothers…

Cannabinoids are compounds that are structurally and/or functionally related to the primary
psychoactive constituent of Cannabis sativa,∆ 9-tetrahydrocannabinol (THC). Cannabinoids …

Neurological crosstalk between the endocannabinoid and estrogen systems has been a
growing topic of discussion over the last decade. Although the main estrogenic ligand, estradiol …