Developing thymocytes are selected for recognition of molecules encoded by the major
histocompatibility complex, purged of self-reactive cells and committed to either the CD4 or CD8 …

Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven
by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily …

The key role played by fucose in glycoprotein and cellular function has prompted significant
research toward identifying recombinant and biochemical strategies for blocking its …

Purpose: CD70 (CD27L) is a member of the tumor necrosis factor family aberrantly expressed
on a number of hematologic malignancies and some carcinomas. CD70 expression on …

Fas ligand (FasL/CD95L/APO-1L) is one of a growing number of TNF family members whose
triggering costimulates maximal proliferation of activated T cells. In this study we show that …

The diversity of naive CD4 T cells plays an important role in the adaptive immune response
by ensuring the capability of responding to novel pathogens. In the past, it has been …

Rheumatoid arthritis (RA) is characterized by inflammation and cellular proliferation in the
synovial lining of joints that result in cartilage and bone destruction. Although the etiology of …

Type 1 diabetes is an autoimmune disease with no cure, where clinical translation of
promising therapeutics has been hampered by the reproducibility crisis. Here, short-term …

Immunotherapy for type 1 diabetes (T1D) has previously focused on suppressing the
autoimmune response against pancreatic beta cells to preserve endogenous insulin production …

Expression of CD70, a member of the tumor necrosis factor superfamily, is restricted to ac-tivated
T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, …