The function of the integrin family of receptors as central mediators of cell-extracellular
matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and …

Computational models of integrin-based adhesion complexes have revealed important insights
into the mechanisms by which cells establish connections with their external environment…

The ability of adherent cells to sense changes in the mechanical properties of their
extracellular environments is critical to numerous aspects of their physiology. It has been well …

Ena/VASP tetramers are processive actin elongation factors that localize to diverse F-actin
networks composed of filaments bundled by different cross-linking proteins, such as filopodia (…

The ability of adherent cells to form adhesions is critical to numerous phases of their physiology.
The assembly of adhesions is mediated by several types of integrins. These integrins …

During fission yeast cytokinesis, actin filaments nucleated by cortical formin Cdc12 are
captured by myosin motors bound to a band of cortical nodes and bundled by cross-linking …

In this article, we present a computational multiscale model for the characterization of subcellular
proteins. The model is encoded inside a simulation tool that builds coarse‐grained (CG…

Conversion of integrins from low to high affinity states, termed activation, is important in
biological processes, including immunity, hemostasis, angiogenesis, and embryonic …

The actin microfilament (F-actin) is a structural and functional component of the cell cytoskeleton.
Notwithstanding the primary role it plays for the mechanics of the cell, the mechanical …

Integrin conformational dynamics are critical to their receptor and signaling functions in
many cellular processes, including spreading, adhesion, and migration. However, assessing …