The numerous neurons and glia that form the brain originate from tightly controlled growth
and division of neural stem cells, regulated systemically by important known stem cell-…

The termination of the proliferation of Drosophila neural stem cells, also known as neuroblasts
(NBs), requires a ‘decommissioning’ phase that is controlled in a lineage-specific manner. …

The tight control of fate transitions during stem cell differentiation is essential for proper tissue
development and maintenance. However, the challenges in studying sparsely distributed …

Tissue development and homeostasis depend on the balance between growth and terminal
differentiation, but the mechanisms coordinating these processes remain elusive. …

A major challenge in cell and developmental biology is the automated identification and
quantitation of cells in complex multilayered tissues. We developed CytoCensus: an easily …

During Drosophila and vertebrate brain development, the conserved transcription factor
Prospero/Prox1 is an important regulator of the transition between proliferation and …

Abstract Development and tissue maintenance require a supply of new cells, which are
generated by division of stem cells and then specialised to perform their function. The …

Tissue maintenance is underpinned by resident stem cells, whose activity is modulated by
microenvironmental cues. Using Drosophila as a simple model to identify regulators of stem …

During Drosophila and vertebrate brain development, termination of neural stem cell (neuroblast)
proliferation and their differentiation require the conserved transcription factor Prospero…

Timing of Drosophila neuroblast decommissioning is controlled in a lineage-specific manner.
Following a prepupal ecdysone pulse, the ecdysone receptor and mediator complex cause …