Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring
in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the …

Greater use of umbilical cord blood (UCB) for hematopoietic cell transplantation (HCT) is
limited by the number of cells in banked units. Ex vivo culture strategies have been increasingly …

Women with pre‐gestational diabetes have a higher risk of producing children with congenital
heart defects (CHDs), caused predominantly by hyperglycemia‐induced oxidative stress. …

Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is
critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan)…

Acute kidney injury is a common disorder that is associated with significant morbidity and
mortality. Point-of-care ultrasonography (PoCUS) is an imaging modality performed at the …

Maternal cigarette smoking is a risk factor for congenital heart defects (CHDs). Nicotine
replacement therapies are often offered to pregnant women following failed attempts of smoking …

Background In Canada, as is found globally, women of reproductive age are a growing
demographic of persons living with HIV. Combination antiretroviral therapy (cART) treatment …

Congenital heart defects (CHDs) account for 1–5% of live births and are the leading cause of
death in the first year life. Pregestational diabetes increases the risk for CHDs over five fold. …

… Tana Saiyin, The University of Western Ontario Supervisor: Dr. Qingping Feng, The … All
experiments included in this thesis were performed by Tana Saiyin in the laboratory of Dr. …

Stromal interaction molecule 1 (STIM1) is an endo/sarcoplasmic reticulum (ER/SR) calcium (Ca
2+) sensor that activates store-operated Ca 2+ entry (SOCE) following Ca 2+ depletion. …