Sphingosine 1-phosphate receptor-1 (S1PR1) is essential for embryonic vascular
development and maturation. In the adult, it is a key regulator of vascular barrier function and …

Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal
mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to …

The inflammatory response is a complex, tightly regulated process activated by tissue wounding,
foreign body invasion, and sterile inflammation. Over the decades, great progress has …

Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis
of intimal hyperplasia indicative of restenosis and other vascular diseases. Fragile-X …

Dyslipidemia, vascular inflammation, obesity, and insulin resistance often overlap and
exacerbate each other. Mutations in low density lipoprotein receptor adaptor protein-1 (LDLRAP1) …

Objectives PPAR genes are known as the important regulators of fatty acid oxidation and
energy homeostasis. PPARα is highly expressed in the embryonic and adult heart. Previous …

Introduction: Hypertension is a major risk factor for heart disease and stroke. Despite current
medication, half a million deaths in the United States include hypertension as a primary …

Introduction Cardiovascular diseases are the leading cause of deaths globally, representing
approximately 31% of deaths per year, 85% of which are due to myocardial infarction (MI) or …

Sphingosine 1-phosphate receptor-1 (S1PR1) is essential for embryonic vascular
development and maturation. In the adult, it is a key regulator of vascular barrier function and …

Introduction Atherosclerotic vascular syndromes account for 50% of all mortality in the
United States, and are a considerable medical and socioeconomic problem contributing to …