LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
…, S Colella, M Groszer, EZ McAuley, TM Caffrey… - Molecular …, 2007 - nature.com
Left–right asymmetrical brain function underlies much of human cognition, behavior and
emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other …
emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other …
[HTML][HTML] A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated
by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We …
by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We …
Haplotype-specific expression of exon 10 at the human MAPT locus
TM Caffrey, C Joachim, S Paracchini… - Human molecular …, 2006 - academic.oup.com
Neurofibrillary tangles composed of exon 10+ microtubule associated protein tau (MAPT)
deposits are the characteristic feature of the neurodegenerative diseases progressive …
deposits are the characteristic feature of the neurodegenerative diseases progressive …
[HTML][HTML] HDL from an Alzheimer's disease perspective
Evidence from human studies, animal models, and bioengineered arteries supports the
hypothesis that HDL protects against cerebrovascular dysfunction in Alzheimer's disease. …
hypothesis that HDL protects against cerebrovascular dysfunction in Alzheimer's disease. …
Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus
TM Caffrey, C Joachim, R Wade-Martins - Neurobiology of aging, 2008 - Elsevier
The microtubule-associated protein tau (MAPT) H1 haplotype shows a strong association to
the sporadic neurodegenerative diseases, progressive supranuclear palsy and corticobasal …
the sporadic neurodegenerative diseases, progressive supranuclear palsy and corticobasal …
Functional MAPT haplotypes: bridging the gap between genotype and neuropathology
TM Caffrey, R Wade-Martins - Neurobiology of disease, 2007 - Elsevier
The microtubule-associated protein tau (MAPT) locus has long been associated with sporadic
neurodegenerative disease, notably progressive supranuclear palsy and corticobasal …
neurodegenerative disease, notably progressive supranuclear palsy and corticobasal …
[HTML][HTML] PDMS organ-on-chip design and fabrication: strategies for improving fluidic integration and chip robustness of rapidly prototyped microfluidic in vitro models
The PDMS-based microfluidic organ-on-chip platform represents an exciting paradigm that
has enjoyed a rapid rise in popularity and adoption. A particularly promising element of this …
has enjoyed a rapid rise in popularity and adoption. A particularly promising element of this …
[PDF][PDF] MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons
…, J Vowles, SA Cowley, R Wade-Martins, TM Caffrey - Stem cell reports, 2017 - cell.com
The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically
associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects …
associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects …
Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease
JE Beevers, TM Caffrey… - Biochemical Society …, 2013 - portlandpress.com
iPSCs (induced pluripotent stem cells) are the newest tool used to model PD (Parkinson's
disease). Fibroblasts from patients carrying pathogenic mutations that lead to PD have been …
disease). Fibroblasts from patients carrying pathogenic mutations that lead to PD have been …
[PDF][PDF] Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons
…, P Kilfeather, JP Connor, HJR Fernandes, TM Caffrey… - Cell Reports, 2023 - cell.com
Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic
risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms, …
risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms, …