Components of multiprotein complexes are routinely determined by using proteomic approaches.
However, this information lacks functional content except when new complex members …

Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of
paused polymerase into productive elongation has emerged as a major mechanism of …

The Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in
eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) …

Mouse macrophages can be stimulated by interferon (IFN)-γ and bacterial lipopolysaccharide
(LPS) to produce nitric oxide (NO) as the result of expression of the inducible NO synthase …

The mammalian ATM/PI 3-kinase-related TRRAP protein was previously found to be a
component of a multi-protein histone acetyltransferase (HAT) complex containing the HAT TIP60. …

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB)
holds great promise for treating a broad spectrum of hematological disorders including …

The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs (ncRNAs)
from the maternally inherited allele, including the largest miRNA cluster in the mammalian …

Biologists have long been fascinated with the organization and function of intricate protein
complexes. Therefore, techniques for precisely imaging protein complexes and the location of …

Hox genes modulate the properties of hematopoietic stem cells (HSCs) and reacquired Hox
expression in progenitors contributes to leukemogenesis. Here, our transcriptome and DNA …

The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator
that plays important roles in activation and repression of RNA polymerase II transcription…