User profiles for Tarmo Aijo
 | Tarmo ÄijöD.Sc. (Tech.) Verified email at coverahealth.com Cited by 3945 |
High-definition spatial transcriptomics for in situ tissue profiling
Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …
to capture both concurrently are lacking. Here, we developed high-definition spatial …
[PDF][PDF] The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
During persistent antigen stimulation, CD8 + T cells show a gradual decrease in effector
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
function, referred to as exhaustion, which impairs responses in the setting of tumors and …
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal
muscle as a consequence of motor neuron degeneration. Interactions between motor …
muscle as a consequence of motor neuron degeneration. Interactions between motor …
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation
The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC)
in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We …
in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We …
[PDF][PDF] Genome-wide analysis of STAT3-mediated transcription during early human Th17 cell differentiation
SK Tripathi, Z Chen, A Larjo, K Kanduri, K Nousiainen… - Cell reports, 2017 - cell.com
The development of therapeutic strategies to combat immune-associated diseases requires
the molecular mechanisms of human Th17 cell differentiation to be fully identified and …
the molecular mechanisms of human Th17 cell differentiation to be fully identified and …
Learning gene regulatory networks from gene expression measurements using non-parametric molecular kinetics
T Äijö, H Lähdesmäki - Bioinformatics, 2009 - academic.oup.com
Motivation: Regulation of gene expression is fundamental to the operation of a cell. Revealing
the structure and dynamics of a gene regulatory network (GRN) is of great interest and …
the structure and dynamics of a gene regulatory network (GRN) is of great interest and …
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
TET (ten-eleven-translocation) proteins are Fe(ii)- and α-ketoglutarate-dependent
dioxygenases 1 , 2 , 3 that modify the methylation status of DNA by successively oxidizing 5-…
dioxygenases 1 , 2 , 3 that modify the methylation status of DNA by successively oxidizing 5-…
[HTML][HTML] Evaluation of methods for detection of fluorescence labeled subcellular objects in microscope images
P Ruusuvuori, T Äijö, S Chowdhury… - BMC …, 2010 - Springer
Background Several algorithms have been proposed for detecting fluorescently labeled
subcellular objects in microscope images. Many of these algorithms have been designed for …
subcellular objects in microscope images. Many of these algorithms have been designed for …
MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs).
Here we show that inflammatory signals regulate Dicer expression in CTLs, and that …
Here we show that inflammatory signals regulate Dicer expression in CTLs, and that …
Control of Foxp3 stability through modulation of TET activity
Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine
and other oxidized methylcytosines, intermediates in DNA demethylation. In this …
and other oxidized methylcytosines, intermediates in DNA demethylation. In this …