The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL
The mammalian cell nucleus contains membraneless suborganelles referred to as nuclear
bodies (NBs). Some NBs are formed with an architectural RNA (arcRNA) as the structural core…
bodies (NBs). Some NBs are formed with an architectural RNA (arcRNA) as the structural core…
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles
Prion-like domains (PLDs) are low complexity sequences found in RNA binding proteins
associated with the neurodegenerative disorder amyotrophic lateral sclerosis. Recently, PLDs …
associated with the neurodegenerative disorder amyotrophic lateral sclerosis. Recently, PLDs …
Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines
T Mannen, M Goto, T Yoshizawa… - Molecular Biology of …, 2021 - Am Soc Cell Biol
The mammalian cell nucleus is a highly organized organelle that contains membrane-less
structures referred to as nuclear bodies (NBs). Some NBs carry specific RNA types that play …
structures referred to as nuclear bodies (NBs). Some NBs carry specific RNA types that play …
[HTML][HTML] Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS (P525L) and FUS (R495X)
A Gonzalez, T Mannen, T Çağatay, A Fujiwara… - Scientific reports, 2021 - nature.com
Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS).
Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of …
Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of …
[HTML][HTML] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
…, M Matsubayashi, Y Shinkai, T Niwa, T Mannen… - Nature …, 2021 - nature.com
Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also
modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic …
modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic …
How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
MC Siomi, T Mannen, H Siomi - Genes & development, 2010 - genesdev.cshlp.org
PIWI (P-element-induced wimpy testis) proteins are a subset of the Argonaute proteins and
are expressed predominantly in the germlines of a variety of organisms, including Drosophila …
are expressed predominantly in the germlines of a variety of organisms, including Drosophila …
[PDF][PDF] Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA biogenesis in Bombyx germ cells
…, YW Iwasaki, Y Murota, A Nagao, T Mannen… - Cell reports, 2015 - cell.com
PIWI-interacting RNA (piRNA) biogenesis consists of two sequential steps: primary piRNA
processing and the ping-pong cycle that depends on reciprocal Slicer-mediated RNA …
processing and the ping-pong cycle that depends on reciprocal Slicer-mediated RNA …
Dss1 associating with the proteasome functions in selective nuclear mRNA export in yeast
T Mannen, T Andoh, T Tani - Biochemical and biophysical research …, 2008 - Elsevier
Dss1p is an evolutionarily conserved small protein that interacts with BRCA2, a tumor suppressor
protein, in humans. The Schizosaccharomyces pombe strain lacking the dss1 + gene (…
protein, in humans. The Schizosaccharomyces pombe strain lacking the dss1 + gene (…
Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori
…, T Sumiyoshi, H Yamazaki, T Mannen… - The EMBO …, 2020 - embopress.org
Silkworm ovarian germ cells produce the Siwi‐pi RNA ‐induced silencing complex (pi RISC
) through two consecutive mechanisms, the primary pathway and the secondary ping‐pong …
) through two consecutive mechanisms, the primary pathway and the secondary ping‐pong …
ArcRNAs and the formation of nuclear bodies
Long noncoding RNAs (lncRNAs) have long been collectively and passively defined as
transcripts that do not encode proteins. However, extensive functional studies performed over …
transcripts that do not encode proteins. However, extensive functional studies performed over …