The surface of a polymeric nanoparticle (NP) is often functionalized with cell-interactive
ligands and/or additional polymeric layers to control NP interaction with cells and proteins. …

G protein coupled receptors have historically been one of the most druggable classes of
cellular proteins. The members of this large receptor gene family couple to primary effectors, G …

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic
candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical …

Background Many neglected tropical infectious diseases affecting humans are transmitted
by arthropods such as mosquitoes and ticks. New mode-of-action chemistries are urgently …

Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger
cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve …

Heterologous sensitization of adenylyl cyclase (also referred to as superactivation, sensitization,
or supersensitization of adenylyl cyclase) is a cellular adaptive response first described …

Adenylyl cyclase 1 (AC1) belongs to a group of adenylyl cyclases (ACs) that are stimulated
by calcium in a calmodulin-dependent manner. Studies with AC1 knockout mice suggest that …

G protein–coupled receptors (GPCRs) often activate multiple signaling pathways, and ligands
may evoke functional responses through individual pathways. These unique responses …

The dopamine D 2 receptor (DRD2) is a G protein-coupled receptor (GPCR) that is generally
considered to be a primary target in the treatment of schizophrenia. First generation …

Novel small‐molecule agents to treat Bordetella pertussis infections are highly desirable, as
pertussis (whooping cough) remains a serious health threat worldwide. In this study, a …