Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor
patient outcomes that accounts for approximately 180,000 deaths each year. Patient outcomes …

Background: HIV infection is a major risk factor for death in childhood pneumonia in HIV-endemic
regions. Improved case management and preventive strategies require better …

The microbiologic etiology of severe pneumonia in hospitalized patients is rarely known in
sub-Saharan Africa. Through a comprehensive diagnostic work-up, we aimed to identify the …

Background Gentamicin has been used for the treatment of gonorrhea in Malawi since 1993.
However, declining clinical cure rates have been suspected. We evaluated current …

Antimicrobial resistance (AMR) is a global threat, including in sub-Saharan Africa. However,
little is known about the genetics of resistant bacteria in the region. In Malawi, there is …

Background Persistent carriage of pneumococcal vaccine serotypes has occurred after
introduction of PCV13 vaccination in Africa but the mechanisms are unclear. We tested the …

Background: Xpert® MTB/RIF is a molecular test for the detection of Mycobacterium tuberculosis
and rifampicin resistance. It is considered to be a great advance over smear microscopy …

Background: Availability and access to the detection of resistance to anti-tuberculosis drugs
remains a significant challenge in Malawi due to limited diagnostic services. The Xpert® MTB…

Background HIV-associated cryptococcal meningitis is a leading cause of AIDS-related
mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of …

Background The effect of childhood pneumococcal conjugate vaccine implementation in
Malawi is threatened by absence of herd effect. There is persistent vaccine-type pneumococcal …