Cohesin is present in almost all active enhancer regions, where it is associated with
transcription factors 1, 2. Cohesin frequently colocalizes with CTCF (CCCTC-binding factor), …

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide
association study meta-analysis of 100,204 CRC cases and 154,587 controls of …

The mucosal epithelium is a common target of damage by chronic bacterial infections and
the accompanying toxins, and most cancers originate from this tissue. We investigated …

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …

ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and
subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene …

Background While dietary fat has been established as a risk factor for colorectal cancer (CRC),
associations between fatty acids (FAs) and CRC have been inconsistent. Using …

Hereditary factors are presumed to play a role in one third of colorectal cancer (CRC) cases.
However, in the majority of familial CRC cases the genetic basis of predisposition remains …

While elevated blood cholesterol has been associated with an increased risk of colorectal
cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian …

The LINE-1 ORF1p transposon protein is pervasively expressed in many cancers and is a
highly specific biomarker of multiple common, lethal carcinomas and their high-risk precursors …

Background: Genes with recurrent codon-specific somatic mutations are likely drivers of
tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a …