The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is
related to uterine aging. Senolytic therapies are an option for reducing health complications …

Caloric restriction (CR) increases the preservation of the ovarian primordial follicular reserve,
which can potentially delay menopause. Rapamycin also increases preservation on the …

Decline in ovarian reserve with advancing age is associated with reduced fertility and the
emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent studies …

The aim of this study was to evaluate the effect of growth hormone (GH) in the maintenance
of the ovarian primordial follicle reserve. Ovaries from 16 mo old GH-deficient Ames Dwarf (df…

Simple Summary MicroRNAs are small, noncoding RNA, around 23 nt long molecules,
expressed in different cell types and involved in post-transcriptional regulation. Importantly, these …

Estrogen signaling is protective against chronic liver diseases, although men and a subset
of women are contraindicated for chronic treatment with 17β-estradiol (17β-E2) or …

Reduced inflammation, increased insulin sensitivity, and protection against cancer are shared
between humans and mice with GH/IGF1 deficiency. Beyond hormone levels, miRNAs are …

The COVID-19 (Coronavirus Disease 2019), caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2), severely affects mainly individuals with pre-existing …

Evidence points to an important role of the growth hormone (GH) in the aging process and
longevity. GH-deficient mice are smaller, live longer than normal littermates, and females …

The mammalian female is born with a limited ovarian reserve of primordial follicles. These
primordial follicles are slowly activated throughout the reproductive lifecycle, thereby …