Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS),
confers protection against malaria in Africa. AS children infected with Plasmodium …

Background In Africa, infant susceptibility to Plasmodium falciparum malaria increases
substantially as fetal hemoglobin (HbF) and maternal immune IgG disappear from circulation. …

Background Red blood cell variants protect African children from severe falciparum malaria.
However, their individual and interactive effects on mild disease and parasite density, and …

Background. Artemisinin resistance, a long parasite clearance half-life in response to artemisinin,
has been described in patients with Plasmodium falciparum malaria in southeast Asia. …

Background α-thalassemia results from decreased production of α-globin chains that make
up part of hemoglobin tetramers (Hb; α 2 β 2 ) and affects up to 50% of individuals in some …

Background In Plasmodium falciparum–infected patients treated with artemisinins, parasitemia
declines through so-called pitting, an innate splenic process that transforms infected red …

Background Plasmodium falciparum elicits host inflammatory responses that cause the
symptoms and severe manifestations of malaria. One proposed mechanism involves formation of …

Colombia aims to eliminate malaria by 2030 but remains one of the highest burden countries
in the Americas. Plasmodium vivax contributes half of all malaria cases, with its control …

Background Inflammatory cytokinemia and systemic activation of the microvascular
endothelium are central to the pathogenesis of Plasmodium falciparum malaria. Recently, ‘parasite-…

Delayed parasite clearance time observed in Southeast Asia provided the first evidence of
Plasmodium falciparum resistance to artemisinins. The ex vivo ring-stage survival assay (RSA…