Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi… - Nature, 2012 - nature.com
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple
organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the …

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

…, A Maeda, H Takahashi, M Mishina, T Haga, K Haga… - Nature, 1986 - nature.com
Cloning and sequence analysis of DNA complementary to porcine cerebral messenger RNA
encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence …

Identification of G protein‐coupled receptor genes from the human genome sequence

S Takeda, S Kadowaki, T Haga, H Takaesu… - FEBS …, 2002 - Wiley Online Library
We have identified novel G protein‐coupled receptors (GPCRs) with no introns in the coding
region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 …

Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants

K Kajiya, K Inaki, M Tanaka, T Haga… - Journal of …, 2001 - Soc Neuroscience
The vertebrate olfactory system discriminates a wide variety of odorants by relaying coded
information from olfactory sensory neurons in the olfactory epithelium to olfactory cortical …

Identification and characterization of the high-affinity choline transporter

T Okuda, T Haga, Y Kanai, H Endou, T Ishihara… - Nature …, 2000 - nature.com
In cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting
step in acetylcholine synthesis. Using information provided by the Caenorhabditis elegans …

Functional identification and reconstitution of an odorant receptor in single olfactory neurons

…, J Hirono, T Sato, H Sakano, T Haga - Proceedings of the …, 1999 - National Acad Sciences
The olfactory system is remarkable in its capacity to discriminate a wide range of odorants
through a series of transduction events initiated in olfactory receptor neurons. Each olfactory …

Molecular properties of muscarinic acetylcholine receptors

T Haga - Proceedings of the Japan Academy, Series B, 2013 - jstage.jst.go.jp
Muscarinic acetylcholine receptors, which comprise five subtypes (M1-M5 receptors), are
expressed in both the CNS and PNS (particularly the target organs of parasympathetic neurons…

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

…, I Akiba, A Mikami, H Takahashi, T Haga, K Haga… - FEBS letters, 1986 - Elsevier
The complete amino acid sequence of the porcine cardiac muscarinic acetylcholine receptor
has been deduced by cloning and sequencing the cDNA. The tissue location of the RNA …

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the Pleckstrin homology domain of 3 types of RAC protein …

…, H Matsuzaki, Y Ono, K Kameyama, T Haga… - Biochemical and …, 1995 - Elsevier
cDNA clones encoding the third member of the RAC protein kinase family, termed RAC-PK γ,
were isolated from a rat brain cDNA library. The deduced amino acid sequence of RAC-PK …

Choline uptake systems of rat brain synaptosomes

T Haga, H Noda - Biochimica et Biophysica Acta (BBA)-Biomembranes, 1973 - Elsevier
The uptake of [ 3 H]choline into synaptosomes and the subsequent synthesis of [ 3 H]acetylcholine
were examined as functions of choline, Na + and hemicholinium-3 concentrations in …