Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi… - Nature, 2012 - nature.com
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple
organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the …
organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the …
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
…, A Maeda, H Takahashi, M Mishina, T Haga, K Haga… - Nature, 1986 - nature.com
Cloning and sequence analysis of DNA complementary to porcine cerebral messenger RNA
encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence …
encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence …
Identification of G protein‐coupled receptor genes from the human genome sequence
S Takeda, S Kadowaki, T Haga, H Takaesu… - FEBS …, 2002 - Wiley Online Library
We have identified novel G protein‐coupled receptors (GPCRs) with no introns in the coding
region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 …
region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 …
Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants
K Kajiya, K Inaki, M Tanaka, T Haga… - Journal of …, 2001 - Soc Neuroscience
The vertebrate olfactory system discriminates a wide variety of odorants by relaying coded
information from olfactory sensory neurons in the olfactory epithelium to olfactory cortical …
information from olfactory sensory neurons in the olfactory epithelium to olfactory cortical …
Identification and characterization of the high-affinity choline transporter
T Okuda, T Haga, Y Kanai, H Endou, T Ishihara… - Nature …, 2000 - nature.com
In cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting
step in acetylcholine synthesis. Using information provided by the Caenorhabditis elegans …
step in acetylcholine synthesis. Using information provided by the Caenorhabditis elegans …
Functional identification and reconstitution of an odorant receptor in single olfactory neurons
…, J Hirono, T Sato, H Sakano, T Haga - Proceedings of the …, 1999 - National Acad Sciences
The olfactory system is remarkable in its capacity to discriminate a wide range of odorants
through a series of transduction events initiated in olfactory receptor neurons. Each olfactory …
through a series of transduction events initiated in olfactory receptor neurons. Each olfactory …
Molecular properties of muscarinic acetylcholine receptors
T Haga - Proceedings of the Japan Academy, Series B, 2013 - jstage.jst.go.jp
Muscarinic acetylcholine receptors, which comprise five subtypes (M1-M5 receptors), are
expressed in both the CNS and PNS (particularly the target organs of parasympathetic neurons…
expressed in both the CNS and PNS (particularly the target organs of parasympathetic neurons…
Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence
…, I Akiba, A Mikami, H Takahashi, T Haga, K Haga… - FEBS letters, 1986 - Elsevier
The complete amino acid sequence of the porcine cardiac muscarinic acetylcholine receptor
has been deduced by cloning and sequencing the cDNA. The tissue location of the RNA …
has been deduced by cloning and sequencing the cDNA. The tissue location of the RNA …
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the Pleckstrin homology domain of 3 types of RAC protein …
…, H Matsuzaki, Y Ono, K Kameyama, T Haga… - Biochemical and …, 1995 - Elsevier
cDNA clones encoding the third member of the RAC protein kinase family, termed RAC-PK γ,
were isolated from a rat brain cDNA library. The deduced amino acid sequence of RAC-PK …
were isolated from a rat brain cDNA library. The deduced amino acid sequence of RAC-PK …
Choline uptake systems of rat brain synaptosomes
T Haga, H Noda - Biochimica et Biophysica Acta (BBA)-Biomembranes, 1973 - Elsevier
The uptake of [ 3 H]choline into synaptosomes and the subsequent synthesis of [ 3 H]acetylcholine
were examined as functions of choline, Na + and hemicholinium-3 concentrations in …
were examined as functions of choline, Na + and hemicholinium-3 concentrations in …