User profiles for Tatyana A. Shelkovnikova

Tatyana Shelkovnikova

SITraN, University of Sheffield
Verified email at sheffield.ac.uk
Cited by 1764

[HTML][HTML] Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor …

TA Shelkovnikova, OM Peters, AV Deykin… - Journal of biological …, 2013 - ASBMB
Dysfunction of two structurally and functionally related proteins, FUS and TAR DNA-binding
protein of 43 kDa (TDP-43), implicated in crucial steps of cellular RNA metabolism can …

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

TA Shelkovnikova, HK Robinson… - Human molecular …, 2014 - academic.oup.com
Paraspeckles are nuclear bodies formed by a set of specialized proteins assembled on the
long non-coding RNA NEAT1; they have a role in nuclear retention of hyperedited transcripts …

[HTML][HTML] The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

…, R Goldstone, O Bandmann, TA Shelkovnikova… - Nature …, 2023 - nature.com
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis,
linking external stimuli to transcriptional co-activation of genes involved in adaptive and …

[HTML][HTML] ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

…, V La Bella, VL Buchman, TA Shelkovnikova - Acta neuropathologica …, 2019 - Springer
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is
known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. …

[HTML][HTML] NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

H An, NG Williams, TA Shelkovnikova - Non-coding RNA research, 2018 - Elsevier
Neurodegenerative diseases are among the most common causes of disability worldwide.
Although neurodegenerative diseases are heterogeneous in both their clinical features and …

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms

TA Shelkovnikova, HK Robinson… - Human molecular …, 2014 - academic.oup.com
Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several
neurodegenerative diseases. Aggregation of mislocalized FUS into non-amyloid inclusions is …

[HTML][HTML] Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

TA Shelkovnikova, MS Kukharsky, H An… - Molecular …, 2018 - Springer
Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA)
NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral …

Stress granules regulate stress-induced paraspeckle assembly

H An, JT Tan, TA Shelkovnikova - Journal of Cell Biology, 2019 - rupress.org
Eukaryotic cells contain a variety of RNA-protein macrocomplexes termed RNP granules.
Different types of granules share multiple protein components; however, the crosstalk between …

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm

TA Shelkovnikova, HK Robinson, N Connor-Robson… - Cell Cycle, 2013 - Taylor & Francis
Fused in sarcoma (FUS) belongs to the group of RNA-binding proteins implicated as
underlying factors in amyotrophic lateral sclerosis (ALS) and certain other neurodegenerative …

[HTML][HTML] ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS …

…, T Iwatsubo, VL Buchman, TA Shelkovnikova - Neurobiology of …, 2022 - Elsevier
Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly
conserved cellular response to stress. Abnormal metabolism of SGs may contribute to the …