INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

The pathophysiology of adverse events following programmed cell death protein 1 (PD-1)
blockade, including tuberculosis (TB) and autoimmunity, remains poorly characterized. We …

Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by a selective
predisposition to clinical disease caused by the Bacille Calmette-Guérin (BCG) vaccine and …

Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the transcription …

Autosomal recessive IRF7 deficiency was previously reported in three patients with single
critical influenza or COVID-19 pneumonia episodes. The patients’ fibroblasts and …

Background Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs)
underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of …

Inborn errors of TLR3-dependent IFN-α/β– and IFN-λ–mediated immunity in the CNS can
underlie herpes simplex virus 1 (HSV-1) encephalitis (HSE). The respective contributions of IFN…

Human inborn errors of IFN-γ underlie mycobacterial disease, due to insufficient IFN-γ
production by lymphoid cells, impaired myeloid cell responses to this cytokine, or both. We report …