Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
Background Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part
through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative type …
through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered lineage-negative type …
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Airway tolerance is the usual outcome of inhalation of harmless antigens. Although T cell
deletion and anergy are likely components of tolerogenic mechanisms in the lung, increasing …
deletion and anergy are likely components of tolerogenic mechanisms in the lung, increasing …
Th9 and allergic disease
P Soroosh, TA Doherty - Immunology, 2009 - Wiley Online Library
Helper CD4 + T‐cell subsets have improved our understanding of adaptive immunity in
humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the …
humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the …
[HTML][HTML] Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting …
…, CA Shibao, DM Systrom, GA Cook, TA Doherty… - Autonomic …, 2021 - Elsevier
Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder
characterized by orthostatic intolerance with excessive heart rate increase without …
characterized by orthostatic intolerance with excessive heart rate increase without …
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6
M Miller, AB Tam, JY Cho, TA Doherty… - Proceedings of the …, 2012 - National Acad Sciences
Orosomucoid like 3 (ORMDL3) has been strongly linked with asthma in genetic association
studies, but its function in asthma is unknown. We demonstrate that in mice ORMDL3 is an …
studies, but its function in asthma is unknown. We demonstrate that in mice ORMDL3 is an …
Diagnosis and management of eosinophilic asthma: a US perspective
HH Walford, TA Doherty - Journal of asthma and allergy, 2014 - Taylor & Francis
Eosinophilic asthma is now recognized as an important subphenotype of asthma based on
the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be …
the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be …
The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
TA Doherty, P Soroosh, N Khorram, S Fukuyama… - Nature medicine, 2011 - nature.com
Individuals with chronic asthma show a progressive decline in lung function that is thought
to be due to structural remodeling of the airways characterized by subepithelial fibrosis and …
to be due to structural remodeling of the airways characterized by subepithelial fibrosis and …
[HTML][HTML] STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria
TA Doherty, N Khorram, JE Chang… - … of Physiology-Lung …, 2012 - journals.physiology.org
Asthma exacerbations can be caused by a number of factors, including the fungal allergen
Alternaria, which is specifically associated with severe and near-fatal attacks. The …
Alternaria, which is specifically associated with severe and near-fatal attacks. The …
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma
…, HM Hoffman, AB Tam, TA Doherty… - The Journal of …, 2014 - journals.aai.org
Orosomucoid-like (ORMDL) 3 has been strongly linked with asthma in genetic association
studies. Because allergen challenge induces lung ORMDL3 expression in wild-type mice, we …
studies. Because allergen challenge induces lung ORMDL3 expression in wild-type mice, we …
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
…, P Rosenthal, F Chouiali, TA Doherty… - Proceedings of the …, 2016 - National Acad Sciences
Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …