SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic.
Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human …

CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As
a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that …

Monoclonal antibodies constitute one of the largest groups of drugs to treat cancers and
immune disorders, and are guiding the design of vaccines against infectious diseases. …

Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit
neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on …

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic. Antibodies are …

Introduction Adjuvants are critical components of vaccines to improve the quality and durability
of immune responses. Molecular adjuvants are a specific subclass of adjuvants where …

The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a
positive co-stimulatory signal to activated T cells upon binding to its ligand (ICOS-L). …

The organization and clustering of cell surface proteins plays a critical role in controlling
receptor signaling; however, the biophysical mechanisms regulating these parameters are not …

Cluster of differentiation-22 (CD22) belongs to the sialic acid–binding immunoglobulin (Ig)-like
lectin family of receptors that is expressed on the surface of B cells. It has been classified …

Glycoproteins on the surface of cells play critical roles in cellular function, including
signalling, adhesion and transport. On leukocytes, several of these glycoproteins possess …