To explore the role of protein kinase A (PKA) in the late phase of long-term potentiation (L-LTP)
and memory, we generated transgenic mice that express R(AB), an inhibitory form of the …

Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons,
and its expression is modulated by neural activity. Knockout mice can be used to study …

Repeated high-frequency trains of stimuli induce long-term potentiation (LTP) in the CA1
region that persists for up to 8 hours in hippocampal slices and for days in intact animals. This …

Memory is often considered to be a process that has several stages, including acquisition,
consolidation and retrieval. Memory can be modified further through reconsolidation and …

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory
and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that …

Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed
gliotransmission. The role of this process in the control of behavior is unknown. Since one …

We have used a combined genetic and pharmacological approach to define the time course
of the requirement for protein kinase A (PKA) and protein synthesis in long-term memory for …

Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms
for regulation of gene expression during brain development and in memory formation. …

Many behavioral and electrophysiological studies in animals and humans have suggested
that sleep and circadian rhythms influence memory consolidation. In rodents, hippocampus-…

Millions of people regularly obtain insufficient sleep 1 . Given the effect of sleep deprivation
on our lives, understanding the cellular and molecular pathways affected by sleep …