High-quality draft assemblies of mammalian genomes from massively parallel sequence data
…, JN Burton, BJ Walker, T Sharpe… - Proceedings of the …, 2011 - National Acad Sciences
Massively parallel DNA sequencing technologies are revolutionizing genomics by making it
possible to generate billions of relatively short (~100-base) sequence reads at very low cost. …
possible to generate billions of relatively short (~100-base) sequence reads at very low cost. …
[HTML][HTML] A structural variation reference for medical and population genetics
Structural variants (SVs) rearrange large segments of DNA 1 and can have profound
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …
[HTML][HTML] Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
…, UD Schumann, B Schwessinger, L Seyer, T Sharpe… - Nature, 2009 - nature.com
Phytophthora infestans is the most destructive pathogen of potato and a model organism for
the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms …
the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms …
[HTML][HTML] Whole-genome resequencing reveals loci under selection during chicken domestication
…, MT Webster, L Jiang, M Ingman, T Sharpe… - Nature, 2010 - nature.com
Domestic animals are excellent models for genetic studies of phenotypic evolution 1 , 2 , 3 .
They have evolved genetic adaptations to a new environment, the farm, and have been …
They have evolved genetic adaptations to a new environment, the farm, and have been …
[HTML][HTML] The genomic substrate for adaptive radiation in African cichlid fish
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic …
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic …
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
…, JE Major, C Hatton, R Nicoletti, M Hanna, T Sharpe… - Nature …, 2010 - nature.com
Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per
year in the United States 1 , show remarkable histologic diversity, with more than 50 …
year in the United States 1 , show remarkable histologic diversity, with more than 50 …
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
…, DC Schwartz, A Sergushichev, T Sharpe… - …, 2013 - academic.oup.com
Background The process of generating raw genome sequence data continues to become
cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished …
cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished …
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
…, J Jurka, M Kamal, E Mauceli, SMJ Searle, T Sharpe… - Nature, 2007 - nature.com
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis
domestica). As the first metatherian (‘marsupial’) species to be sequenced, the …
domestica). As the first metatherian (‘marsupial’) species to be sequenced, the …
[HTML][HTML] The African coelacanth genome provides insights into tetrapod evolution
…, G Scapigliati, SMJ Searle, T Sharpe… - Nature, 2013 - nature.com
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of
lobe-finned fish was thought to have become extinct 70 million years ago. The modern …
lobe-finned fish was thought to have become extinct 70 million years ago. The modern …
Assemblathon 1: a competitive assessment of de novo short read assembly methods
…, D Przybylski, FJ Ribeiro, S Yin, T Sharpe… - Genome …, 2011 - genome.cshlp.org
Low-cost short read sequencing technology has revolutionized genomics, though it is only
just becoming practical for the high-quality de novo assembly of a novel large genome. We …
just becoming practical for the high-quality de novo assembly of a novel large genome. We …