The eukaryotic epigenome is shaped by the genome topology in three-dimensional space.
Dynamic reversible variations in this epigenome structure directly influence the …

The transcriptional coactivator ANGUSTIFOLIA3 (AN3) stimulates cell proliferation during
Arabidopsis thaliana leaf development, but the molecular mechanism is largely unknown. Here…

Noncoding RNAs have emerged as major components of the eukaryotic transcriptome.
Genome-wide analyses revealed the existence of thousands of long noncoding RNAs (lncRNAs) …

In eukaryotes, three-dimensional genome organization is critical for transcriptional
regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin …

Mammalian chromosomes are partitioned into A/B compartments and topologically
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …

Extensive 3D folding is required to package a genome into the tiny nuclear space, and this
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …

Precise expression patterns of genes in time and space are essential for proper development
of multicellular organisms. Dynamic chromatin conformation and spatial organization of the …

Background Microbial-associated molecular patterns activate several MAP kinases, which
are major regulators of the innate immune response in Arabidopsis thaliana that induce large-…

SWI/SNF complexes mediate ATP-dependent chromatin remodeling to regulate gene
expression. Many components of these complexes are evolutionarily conserved, and several …

The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and
facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape …