User profiles for Teemu Daniel Laajala
 | Teemu Daniel LaajalaUniversity of Turku Verified email at utu.fi Cited by 1641 |
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
Kinase inhibitor resistance constitutes a major unresolved clinical challenge in cancer.
Furthermore, the role of serine/threonine phosphatase deregulation as a potential cause for …
Furthermore, the role of serine/threonine phosphatase deregulation as a potential cause for …
[HTML][HTML] Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1
Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor
suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of protein …
suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of protein …
[HTML][HTML] A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions
Endometriosis is a common inflammatory estrogen-dependent gynecological disorder,
associated with pelvic pain and reduced fertility in women. Several aspects of this disorder and its …
associated with pelvic pain and reduced fertility in women. Several aspects of this disorder and its …
[HTML][HTML] Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling
O Kauko, TD Laajala, M Jumppanen, P Hintsanen… - Scientific reports, 2015 - nature.com
Hyperactivated RAS drives progression of many human malignancies. However, oncogenic
activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) …
activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) …
[HTML][HTML] Group polarisation among location-based game players: an analysis of use and attitudes towards game slang
Purpose This study investigates how game design, which divides players into static teams,
can reinforce group polarisation. The authors study this phenomenon from the perspective of …
can reinforce group polarisation. The authors study this phenomenon from the perspective of …
Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding
…, N Blank, M Balbach, H Turunen, TD Laajala… - Molecular and Cellular …, 2016 - Elsevier
During epididymal maturation, sperm acquire the ability to swim progressively by interacting
with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in …
with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in …
[HTML][HTML] Female doping: observations from a data lake study in the Hospital District of Helsinki and Uusimaa, Finland
PK Vauhkonen, TD Laajala, KM Lindroos… - BMC Women's …, 2023 - Springer
Background Doping is a well-recognized risk factor for several potentially severe health effects.
Scientific literature concerning the need for medical treatment for such adversities is still …
Scientific literature concerning the need for medical treatment for such adversities is still …
[HTML][HTML] CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection
…, B Au-Yeung, E Sittig, TD Laajala… - PLoS …, 2016 - journals.plos.org
The oncoprotein Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is overexpressed
in most malignancies and is an obvious candidate target protein for future cancer therapies. …
in most malignancies and is an obvious candidate target protein for future cancer therapies. …
Rules for PP2A-controlled phosphosignalling and drug responses
Systemic understanding of protein phosphatase 2A (PP2A)-regulated cellular processes is
still at infancy. Here, we present mass-spectrometry analysis of phospho-targets (…
still at infancy. Here, we present mass-spectrometry analysis of phospho-targets (…
MRI-Targeted Prostate Biopsy Introduces Grade Inflation and Overtreatment
…, TP Lehto, A Erickson, T Shadbahr, TD Laajala… - medRxiv, 2024 - medrxiv.org
Purpose: The use of MRI-targeted biopsies has led to lower detection of Gleason Grade Group
1 (GG1) prostate cancer and increased detection of GG2 disease. Although this finding is …
1 (GG1) prostate cancer and increased detection of GG2 disease. Although this finding is …