The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis,
acute anterior uveitis, reactive arthritis, and psoriatic arthritis, but its mechanism of risk …

Abiotic stresses cause accumulation of reactive oxygen species (ROS), such as hydrogen
peroxide (H 2 O 2 ) in plants. Sophisticated mechanisms are required to maintain optimum …

We are beginning to appreciate the complex relationship between the gut microbiome and
host immune regulation and dysregulation in health and disease. Potentially important …

Objective To investigate whether HLA –B27–mediated experimental spondyloarthritis (SpA)
is associated with a common gut microbial signature, in order to identify potential drivers of …

… GILL ET AL 1850 | … GILL ET AL 1852 | … Gill had full access to all of the data in the study
and takes responsibility for the integrity of the data and the accuracy of the data analysis. …

The mechanism by which HLA-B*27 predisposes to spondyloarthritis remains unresolved.
Arthritogenic peptides have not been defined in humans and are not involved in experimental …

T cell receptor (TCR)-initiated signal transduction is reported to increase production of
intracellular reactive oxygen species, such as superoxide (O 2 ⨪ ) and hydrogen peroxide (H 2 O …

Antioxidant enzymes play a significant role in eliminating toxic levels of reactive oxygen
species (ROS), generated during stress from living cells. In the present study, two different …

Hydrogen peroxide (H 2 O 2 ) is known to accumulate in plants during abiotic stress conditions
and also acts as a signalling molecule. In this study, Arabidopsis thaliana transgenics …

Transforming growth factor (TGF)-β, is an immunosuppressive cytokine that inhibits T-cell
activation. We hypothesized that TGF-β mediates its immunoinhibitory effects by modulation of …