Les récepteurs couplés aux protéines G (RCPG) représentent la plus grande famille de
récepteurs membranaires impliqués dans la transmission de signaux. Chez l'humain, plusieurs …

Au cours des dernières années, un nombre croissant de données expérimentales ont démontré
que beaucoup de récepteurs couplés aux protéines G (RCPGs) sont structurellement et …

G protein–coupled receptors (GPCRs) represent the largest family of proteins involved in
signal transduction. Here we present a bioluminescence resonance energy transfer (BRET) …

Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with Gα subunits. However, the …

The role of Gβγ subunits in cellular signaling has become well established in the past 20 years.
Not only do they regulate effectors once thought to be the sole targets of Gα subunits, but …

Dopamine‐modulated behaviors, including information processing and reward, are subject
to behavioral plasticity. Disruption of these behaviors is thought to support drug addictions …

β 1 - and β 2 -adrenergic receptors (β 1 AR and β 2 AR) are co-expressed in numerous
tissues where they play a central role in the responses of various organs to sympathetic …

A large number of studies have demonstrated co-purification or co-immunoprecipitation of
receptors with G proteins. We have begun to look for the presence of effector molecules in …

Cardiomyocytes from the pulmonary vein sleeves (PVs) are known to play an important role
in atrial fibrillation. PVs have been shown to exhibit time‐dependent hyperpolarization‐…

G protein-coupled receptors are commonly thought to bind their cognate ligands and elicit
functional responses primarily as monomeric receptors. In studying the recombinant γ-…