Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed
in lethal yellow (A y) mice, and causes obesity by mimicking agouti-related protein (Agrp)…

mahoganoid is a mouse coat-color mutation whose pigmentary phenotype and genetic
interactions resemble those ofAttractin (Atrn). Atrn mutations also cause spongiform …

Agouti protein and agouti-related protein are homologous paracrine signalling molecules
that normally regulate hair colour and body weight, respectively, by antagonizing signalling …

Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene
discovery, but mutation identification is often difficult. We present the first study in which an …

The pigment‐type switching system, which controls whether melanocytes produce black/brown
eumelanin or yellow/red pheomelanin, is responsible for many familiar coat coloration …

Mahogunin Ring Finger 1 (Mgrn1) encodes a RING‐containing protein with ubiquitin ligase
activity that has been implicated in pigment‐type switching. In addition to having dark fur, …

Spongiform neurodegeneration is characterized by the appearance of vacuoles throughout
the central nervous system. It has many potential causes, but the underlying cellular …

Switching from eumelanin to pheomelanin synthesis during hair growth is accomplished by
transient synthesis of Agouti protein, an inverse agonist for the melanocortin‐1 receptor (Mc1r…

Objective —To determine whether a mutation in the fibrillin 2 gene ( FBN2 ) is associated with
canine hip dysplasia (CHD) and osteoarthritis in dogs. Animals —-1,551 dogs. Procedures …

The etiology of congenital heart defects (CHDs), which are among the most common human
birth defects, is poorly understood because of its complex genetic architecture. Here, we …