Hair cells have highly organized bundles of apical projections, or stereocilia, that are
deflected by sound and movement. Displacement of stereocilia stretches linkages at the tips of …

Hair cells detect sound and movement and transmit this information via specialized ribbon
synapses. Here we report that asteroid, a gene identified in an ethylnitrosourea mutagenesis …

The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the
inner ear. The central element of the HC's transduction apparatus is a mechanically gated …

The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and
consist of calcium carbonate crystallites embedded in a protein framework. We report that …

Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and
behavioral research. Physiological similarity to mammals, ease of genetic manipulations, …

The molecular basis of sensory hair cell mechanotransduction is largely unknown. In order
to identify genes that are essential for mechanosensory hair cell function, we characterized a …

The zebrafish is an excellent model system for studying the molecular basis of inner ear
development and function. The eggs develop ex utero and the ear is transparent for the first few …

The zebrafish (Danio rerio) possesses two mechanosensory organs believed to be
homologous to each other: the inner ear, which is responsible for the senses of audition and …

Mechanosensitive cilia are vital to signaling and development across many species. In sensory
hair cells, sound and movement are transduced by apical hair bundles. Each bundle is …

The tip link protein protocadherin 15 (PCDH15) is a central component of the mechanotransduction
complex in auditory and vestibular hair cells. PCDH15 is hypothesized to relay …