Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

Personality can be thought of as a set of characteristics that influence people's thoughts,
feelings and behavior across a variety of settings. Variation in personality is predictive of many …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic inflammation …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …