Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …

Heritability analyses of genome-wide association study (GWAS) cohorts have yielded
important insights into complex disease architecture, and increasing sample sizes hold the …

Multiple methods have been developed to estimate narrow-sense heritability, h 2 , using
single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive …

To investigate the extent to which the proportion of schizophrenia's additive genetic variation
tagged by SNPs is shared by populations of European and African descent, we analyzed …

Heritability is a fundamental parameter in genetics. Traditional estimates based on family or
twin studies can be biased due to shared environmental or non-additive genetic variance. …

Background: Evidence suggests that genetic factors may influence both schizophrenia (Scz)
and its clinical presentation. In recent years, genome-wide association studies (GWAS) …

Highlights • We describe a research paradigm at the intersection of evolutionary psychology
and behavioral genetics. • Genetically informative designs can answer evolutionary …

Genome-wide significant associations generally explain only a small proportion of the
narrow-sense heritability of complex disease (h 2 ). While considerably more heritability is …