The human T cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that persists as
a provirus in the genome of infected cells and can lead to adult T cell leukemia (ATL). …

Tyrosine site-specific recombinases (SSRs) represent a versatile genome editing tool with
considerable therapeutic potential. Recent developments to engineer and evolve SSRs into …

Despite advances in nuclease-based genome editing technologies, correcting human
disease-causing genomic inversions remains a challenge. Here, we describe the potential use of …

Site-specific recombinases (SSRs) such as the Cre/loxP system are useful genome engineering
tools that can be repurposed by altering their DNA-binding specificity. However, SSRs …

<p>Animals harbor specialized neuronal systems that are used for sensing and
coordinating responses to changes in oxygen (O₂) and carbon dioxide (CO₂). …

Recombinases have several potential advantages as genome editing tools compared to
nucleases and other editing enzymes, but the process of engineering them to efficiently …

Monitoring of neuronal activity within circuits facilitates integrated responses and rapid
changes in behavior. We have identified a system in Caenorhabditis elegans where …

Oxygen (O 2 ) and carbon dioxide (CO 2 ) provoke distinct olfactory behaviors via specialized
sensory neurons across metazoa. In the nematode C. elegans, the BAG sensory neurons …

Abstract Development of complex nervous systems requires precisely controlled neurogenesis.
The generation and specification of neurons occur through the transcriptional and post-…

Animals use behavioral strategies to seek optimal environments. Population behavioral
assays provide a robust means to determine the effect of genetic perturbations on the ability of …