Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk
of mortality in infected people over 85 years of age remains high. Here we investigate …

Currently, therapeutics for COVID‐19 are limited. To overcome this, it is important that we
use physiologically relevant models to reproduce the pathology of infection and evaluate the …

The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites
inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro…

Background DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared
using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine …

Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis
(TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure …

The airway epithelium is a protective barrier that is maintained by the self-renewal and
differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases…

SARS-CoV-2 initially infects cells in the nasopharynx and oral cavity. The immune system at
these mucosal sites plays a crucial role in minimizing viral transmission and infection. To …

… Alice Halliday,1,2 Pooja Jain,1,3† Long Hoang,1† Robert Parker,1† Mica Tolosa-Wright,1†
Tereza Masonou,1 Nathan Green,4,5,6,7 Aime Boakye,1,3 Yemisi Takwoingi,8,9 Shea …

Children infected with SARS-CoV-2 rarely progress to respiratory failure, but the risk of mortality
in infected people over 85 years of age remains high, despite vaccination and improving …

Background Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a
significant challenge, particularly in high-income, low-incidence settings. Measurement of …