Antibodies specific for peptides bound to human leukocyte antigen (HLA) molecules are
valuable tools for studies of antigen presentation and may have therapeutic potential. Here, we …

We here report a novel phage display selection strategy enabling fast and easy selection of
thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-…

Phage display has been instrumental in discovery of novel binding peptides and folded
domains for the past two decades. We recently reported a novel pIX phagemid display system …

Selection of biased T cell receptor (TCR) repertoires across individuals is seen in both infectious
diseases and autoimmunity, but the underlying molecular basis leading to these shared …

Cancer immunotherapy has finally come of age, demonstrated by recent progress in strategies
that engage the endogenous adaptive immune response in tumor killing. Occasionally, …

Targeting of T cell epitopes to APC enhances T cell responses. We used an APC-specific Ab
(anti-IgD) and substituted either of 18 loops connecting β strands in human IgG constant H (…

Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation
and thus, is a potent strategy for making more efficacious vaccines. This can be achieved …

Antibodies specific for antigenic peptides bound to major histocompatibility complex (MHC)
molecules are valuable tools for studies of antigen presentation. Such T-cell receptor (TCR)-…

Abstracts 1. Production of soluble peptide-MHC class II-Ig fusion proteins The aim of the
study is to construct soluble variants of the murine MHC class II molecule I-Ed in complex with …

… The biotinylated mAbs GB113(49) and AB10 (Frigstad et. al. submitted) were kind gifts from
Professor Bjarne … This experiment was performed by Geir Åge Løset and Terje Frigstad …