[HTML][HTML] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
…, A Muruato, J Zou, X Zhang, T Juelich… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
has led to a worldwide pandemic 1 —has a furin cleavage site (PRRAR) in its spike protein …
[HTML][HTML] Furin cleavage site is key to SARS-CoV-2 pathogenesis
…, A Muruato, J Zou, X Zhang, T Juelich… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world.
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin …
[HTML][HTML] Favipiravir (T-705) protects against Nipah virus infection in the hamster model
BE Dawes, B Kalveram, T Ikegami, T Juelich… - Scientific reports, 2018 - nature.com
Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus
Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates …
Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates …
Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses
…, RF Johnson, CJ Myers, TL Juelich… - Journal of …, 2011 - Am Soc Microbiol
The search for a safe and efficacious vaccine for Ebola virus continues, as no current vaccine
candidate is nearing licensure. We have developed (i) replication-competent, (ii) replication…
candidate is nearing licensure. We have developed (i) replication-competent, (ii) replication…
T-705 (favipiravir) inhibition of arenavirus replication in cell culture
M Mendenhall, A Russell, T Juelich… - Antimicrobial agents …, 2011 - Am Soc Microbiol
A number of New World arenaviruses (Junín [JUNV], Machupo [MACV], and Guanarito [GTOV]
viruses) can cause human disease ranging from mild febrile illness to a severe and often …
viruses) can cause human disease ranging from mild febrile illness to a severe and often …
[HTML][HTML] A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
…, G Roman-Sosa, LR Robinson, TL Juelich… - PLoS …, 2013 - journals.plos.org
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped
viruses at non-cytotoxic concentrations (IC 50 ≤0.5 µM), and was posited to exploit the …
viruses at non-cytotoxic concentrations (IC 50 ≤0.5 µM), and was posited to exploit the …
[HTML][HTML] Favipiravir (T-705) inhibits Junin virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever
BB Gowen, TL Juelich, EJ Sefing, T Brasel… - PLoS neglected …, 2013 - journals.plos.org
Background Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF),
is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral …
is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral …
Rift Valley fever virus MP-12 vaccine is fully attenuated by a combination of partial attenuations in the S, M, and L segments
…, TE Hill, JK Smith, L Zhang, TL Juelich… - Journal of …, 2015 - Am Soc Microbiol
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and
characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or …
characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or …
Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of …
…, A Park, TE Hill, O Pernet, SM Beaty, TL Juelich… - Journal of …, 2015 - Am Soc Microbiol
Nipah virus (NiV) and Hendra virus (HeV) are closely related henipaviruses of the
Paramyxovirinae . Spillover from their fruit bat reservoirs can cause severe disease in humans and …
Paramyxovirinae . Spillover from their fruit bat reservoirs can cause severe disease in humans and …
A single sublingual dose of an adenovirus-based vaccine protects against lethal Ebola challenge in mice and guinea pigs
…, L Zhang, GP Kobinger, T Juelich… - Molecular …, 2012 - ACS Publications
Sublingual (SL) delivery, a noninvasive immunization method that bypasses the intestinal
tract for direct entry into the circulation, was evaluated with an adenovirus (Ad5)-based …
tract for direct entry into the circulation, was evaluated with an adenovirus (Ad5)-based …