M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by
conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are …

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC)
permeases serve as the primary import pathway for many micronutrients including the first-row …

Human Tim8a and Tim8b are paralogous intermembrane space proteins of the small TIM
chaperone family. Yeast small TIMs function in the trafficking of proteins to the outer and inner …

There is an urgent clinical need for antimalarial compounds that target malaria caused by
both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases …

The nematode Caenorhabditis elegans contains genes for two types of ferritin (ftn-1 and ftn-2)
that express FTN-1 and FTN-2. We have expressed and purified both proteins and …

Plasmodium falciparum, the causative agent of malaria, remains a global health threat as
parasites continue to develop resistance to antimalarial drugs used throughout the world. …

The family of M17 aminopeptidases (alias ‘leucine aminopeptidases’, M17-LAPs) utilize a
highly conserved hexameric structure and a binuclear metal center to selectively remove N-…

During malarial infection, Plasmodium parasites digest human hemoglobin to obtain free
amino acids for protein production and maintenance of osmotic pressure. The Plasmodium M1 …

Malaria remains a global health threat and growing resistance to artemisinin-based therapies
calls for therapeutic agents with novel mechanisms of action. The Plasmodium spp M1 and …

The metal-dependent M17 aminopeptidases are conserved throughout all kingdoms of life.
This large enzyme family is characterized by a conserved binuclear metal center and a …