[PDF][PDF] Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo
T Dignum, B Varnum-Finney, SR Srivatsan, S Dozono… - Cell reports, 2021 - cell.com
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). …
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs). …
[HTML][HTML] Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics
…, B Varnum-Finney, S Dozono, T Dignum… - Nature …, 2022 - nature.com
Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …
Dermatologic complications in pediatric patients after hematopoietic stem cell transplantation for sickle cell disease
T Dignum, L Burroughs, K Mallhi… - Pediatric …, 2024 - Wiley Online Library
Dermatologic complications are common following allogeneic hematopoietic stem cell
transplantation, but dermatologic complications among pediatric patients undergoing …
transplantation, but dermatologic complications among pediatric patients undergoing …
Distinct transcriptional signatures distinguish the emergence of multipotent progenitors and hematopoietic stem cells from endothelial precursors in the murine embryo
T Dignum, B Varnum-Finney, S Srivatsan, S Dozono… - Blood, 2020 - Elsevier
During embryonic development, blood cells emerge from hemogenic endothelium (HE),
producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic …
producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic …
Multipotent progenitors and hematopoietic stem cells arise independently during the endothelial to hematopoietic transition in the early mouse embryo
T Dignum, B Varnum-Finney, S Srivatsan, S Dozono… - bioRxiv, 2021 - biorxiv.org
During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). …
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSC). …
Integrated single cell transcriptomics defines an engineered niche supporting hematopoietic stem cell development ex vivo
B Hadland, B Varnum-Finney, S Dozono, T Dignum… - Blood, 2019 - Elsevier
During embryonic development, hematopoietic stem cells (HSC) arise from hemogenic
endothelial cells (HEC) within arterial vessels such as the aorta of the AGM (aorta-gonad-…
endothelial cells (HEC) within arterial vessels such as the aorta of the AGM (aorta-gonad-…
[HTML][HTML] Generating Hematopoietic Stem Cells from AGM-derived Hemogenic Precursors in a Stroma-free Engineered Niche
T Dignum, B Varnum-Finney, S Dozono, B Hadland - 2022 - researchsquare.com
Our previous studies demonstrated the capacity of a stroma layer consisting of AGM-derived
myrAKT-transduced endothelial cells (AGM-EC) to support the in vitro conversion of …
myrAKT-transduced endothelial cells (AGM-EC) to support the in vitro conversion of …
[HTML][HTML] 3063–DISTINCT POPULATIONS OF MULTIPOTENT PROGENITORS AND HEMATOPOIETIC STEM CELLS EMERGE FROM HEMOGENIC ENDOTHELIUM …
T Dignum, B Varnum-Finney, S Srivatsan… - Experimental …, 2020 - Elsevier
During embryonic development, blood cells emerge from hemogenic endothelium (HE),
producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic …
producing waves of hematopoietic progenitors prior to the emergence of rare hematopoietic …
2013–DISSECTING THE UNIQUE TRANSCRIPTOME OF HEMATOPOIETIC STEM CELL-COMPETENT HEMOGENIC ENDOTHELIUM IN THE EARLY MOUSE …
B Hadland, T Dignum, B Varnum-Finney… - Experimental …, 2021 - Elsevier
Hematopoietic stem cells (HSCs) possess the unique ability to engraft a suitably conditioned
host, generate all cell types of the adult hematopoietic system, and self-renew for life, …
host, generate all cell types of the adult hematopoietic system, and self-renew for life, …
[HTML][HTML] Generation of AGM-derived Akt-EC (AGM-EC)
T Dignum, B Varnum-Finney, S Dozono, B Hadland - 2020 - researchsquare.com
During murine embryonic development, the first hematopoietic stem cells (HSCs) emerge
within the major arterial vasculature, including the aorta-gonad-mesonephros (AGM) region. …
within the major arterial vasculature, including the aorta-gonad-mesonephros (AGM) region. …