Background The prefrontal cortex (PFC) has been implicated in the pathophysiology of social
dysfunction, but the specific circuit partners mediating PFC function in health and disease …

Excitatory synapses onto somatostatin (SOM) interneurons show robust short-term facilitation.
This hallmark feature of SOM interneurons arises from a low initial release probability that …

Throughout development, neuronal identity is controlled by key transcription factors that
determine the unique properties of a cell. During embryogenesis, the transcription factor Prox1 …

Microglia play a key role in shaping the formation and refinement of the excitatory network
of the brain. However, less is known about whether and how they organize the development …

The vibrissae system of rodents, akin to human hands and fingers, provides somatosensory
information coming from individual whiskers for object exploration and recognition. Just as …

Degree: M. Sc. DegreeYear: 2002 Institute: University of Alberta (Canada) Adviser: Teresa
Krukoff. Adrenomedullin (ADM) is a neuropeptide that acts in the central nervous system (CNS…

Cortical inhibitory interneurons vary dramatically in shape, gene expression pattern,
electrophysiological 32 and synaptic properties and in their downstream targets [1]. Some cell types, …

Environmental cues associated with rewards, such as food or substances of abuse, often
prompt approach and consummatory actions that are difficult to override, even when restraint …

Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal
signals across multiple neuronal cell types. Here, we combine cell-type-specific …