Computer-aided drug design (CADD) is one of the pivotal approaches to contemporary pre-clinical
drug discovery, and various computational techniques and software programs are …

Peptidoglycan, the exoskeleton of bacterial cell and an essential barrier that protects the cell,
is synthesized by a pathway where the final steps are catalysed by transpeptidases. …

… Thandokuhle Ntombela … I would also like to thank Thandokuhle Ntombela for assisting in
revising this … Nyembe PL, Ntombela T, Makatini MM. Review: Structure-Activity Relationship of …

Tuberculosis remains a dreadful disease that has claimed many human lives worldwide
and elimination of the causative agent Mycobacterium tuberculosis also remains elusive. …

Mycobacterium tuberculosis cell wall is intricate and impermeable to many agents. AD, D-carboxypeptidase
(DacB1) is one of the enzymes involved in the biosynthesis of cell wall …

Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes
have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One …

β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …

Cationic chitosan derivatives have been widely studied as potential antimicrobial agents.
However, very little is known about their antiviral activity and mode of action against enveloped …

Human T-cell leukemia virus type-1 (HTLV-1) is the first pathogenic retrovirus discovered in
human. Although HTLV-1-induced diseases are well-characterized and linked to the …

Mycobacterium tuberculosis is the causative agent of Tuberculosis. Formation of 3 → 3 crosslinks
in the peptidoglycan layer of M. tuberculosis is catalyzed by l,d-transpeptidases. These …