Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy,
but, other than TP53 mutations, few causative somatic aberrations have been identified. …

BACKGROUND: Mutations in the human filaggrin gene (FLG) are associated with atopic
dermatitis (AD) and are presumed to provoke a barrier abnormality. Yet additional acquired …

Two-photon fluorescence lifetime imaging is used to identify microdomains (1–25μm) of two
distinct pH values within the uppermost layer of the epidermis (stratum corneum). The …

Timely intervention for cancer requires knowledge of its earliest genetic aberrations.
Sequencing of tumors and their metastases reveals numerous abnormalities occurring late in …

The outermost epidermal layer, the stratum corneum (SC), exhibits an acidic surface pH,
whereas the pH at its base approaches neutrality. NHE1 is the only Na + /H + antiporter isoform …

Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …

Aged skin commonly is afflicted by inflammatory skin diseases or xerosis/eczema that could
be triggered or exacerbated by impaired epidermal permeability barrier homeostasis. This …

Perturbations in the transcriptional programs specifying epidermal differentiation cause
diverse skin pathologies ranging from impaired barrier function to inflammatory skin disease. …

Mutations in the SPINK5 gene encoding the serine protease (SP) inhibitor, lymphoepithelial-Kazal-type
5 inhibitor (LEKTI), cause Netherton syndrome (NS), a life-threatening disease, …

To determine whether pigment type determines differences in epidermal function, we studied
stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three …