Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

Human monocytes are divided in three major populations; classical (CD14 + CD16 − ), non-classical
(CD14 dim CD16 + ), and intermediate (CD14 + CD16 + ). Each of these subsets is …

Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …

Phagocytosis of pathogens, apoptotic cells and debris is a key feature of macrophage function
in host defense and tissue homeostasis. Quantification of macrophage phagocytosis in …

The recruitment of monocytes and their differentiation into macrophages at sites of inflammation
are key events in determining the outcome of the inflammatory response and initiating …

Macrophages function as sentinel cells, which constantly monitor the host environment for
infection or injury. Macrophages have been shown to exhibit a spectrum of activated …

Systemic inflammation is established as part of late-stage severe lung disease, but molecular,
functional, and phenotypic changes in peripheral immune cells in early disease stages …

Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised
by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a …

Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive
pulmonary disease (COPD) are far from being understood. Here, we determine disease-…