Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent
degradation of proteins. TPD is of interest in drug development, as it can address …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate
tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive …

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in
human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is …

The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other
diseases. However, the therapeutic potential of targeting these kinases is understudied due …

Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks), a family of three members in mammals
(α, β and γ), have emerged as potential therapeutic targets due to their role in regulating …

Phosphatidylinositol 5‐phosphate 4‐kinase, type II, gamma (PIP4K2C) remains a poorly
understood lipid kinase with minimal enzymatic activity but potential scaffolding roles in immune …

Due to their role in many important signaling pathways, phosphatidylinositol 5-phosphate 4-kinases
(PI5P4Ks) are attractive targets for the development of experimental therapeutics for …

Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are important molecular players in a
variety of diseases, such as cancer. Currently available PI5P4K inhibitors are reversible …

The peptidyl-prolyl cis-trans isomerase, Pin1, acts as a unified signaling hub that is exploited
in cancer to activate oncogenes and inactivate tumor suppressors, in particular through up-…